Essential oil from seeds extracted using solvent extraction and SFE method and analyzed by GC-MS [ 94] For treatment of toothache, sore throat, halitosis in Cameroon mouthwash gargle of Eucalyptus saligna is used [ 3] Juniperus communis, commonly known as Juniper and Aaraar, is an evergreen aromatic shrub that belongs to the Cupressaceae family. It is distributed throughout cold and temperate regions of the Himalayan regions, mainly in Kashmir, Bhutan, and western Tibet, at an altitude of 2743 to 4572 m above sea level. Four species of genus Juniperus: Juniperus indica Bertol., Juniperus recurve Buch.-Ham. ex D. Don., Juniperus squamata Buch.-Ham. ex D. Don., and Juniperus communis L., were reported from Uttarakhand [ 128]. The bark part of Juniperus procera Hochst. ex Endl. is used to cure toothache in Ethiopia [ 129]. A recent study reported that a correlation is found between the quantity of phosphate and calcium ions in the Juniperus communis toothpaste. The toothpaste of J. communis was linked with high phosphate concentration due to the presence of pyrophosphate in its composition. The antioxidant effect of Juniperus communis is reported to prevent the biological system from oxidative damage caused by a reactive form of oxygen (H 2O 2 and OH) [ 130]. The study on the species of Juniperus communis reported the plant to have potential use in dental practice. The plant can be used as an effective antimicrobial agent due to the availability of terpene in essential oil composition [ 131]. Used in toothpaste, mouth rinse, and aromatherapy for prevention and treatment of oral infection [ 12, 38] Protecting your mouth is super important to overall health. Visiting your dentist once per year, or even more often can help reduce the risk of any disease or oral problems. Although we may not always find the time to go to the dentist, there are often things you can do at home to help protect your oral health. In this article, we discuss one way you can improve your oral health. WIth eucalyptus oil, you can prevent disease, gum deterioration and more. Below is just one simple recipe that you can use with the oil.

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To compare the efficacy of three different herbal products in gingival inflammation, bacterial count, and reducing plaque in comparison with chlorhexidine M gel among participants with moderate to severe periodontitis. The Middle East, southern European continent, North Africa, India: Bengal, Bihar, Gangetic plains, Himachal Pradesh, Assam, Maharashtra, and Punjab [ 93] So, with three really affordable beneficial ingredients that are most probably hanging about in your cupboards, you can say “bye-bye” to a lifetime of plastic tubes and synthetic chemicals in your toothpaste. Hydrodistillation method for extraction and GC-MS method for the identification. Extraction of essential oil from aerial parts [ 61]

Expert Opinion on Drug Delivery: “Potential benefits of chewing gum for the delivery of oral therapeutics and its possible role in oral healthcare.” In vitro study for dental caries and plaque. Methanol and acetone extracts were screened against bacteria Streptococcus mutans ATCC 25175, Streptococcus salivarius ATCC 13419, Porphyromonas gingivalis ATCC 33277, and Fusobacterium nucleatum ATCC 25586. The current review focus on the beneficial effect of secondary metabolites derived from medicinal plants in oral health. The eligibility of studies includes the following inclusion criteria: (i) medicinal plants that were having less reviewed literature and found rarely were selected; (ii) studies published in the English language were included; (iii) original studies were selected that examined the efficacy of essential oils in oral health; and (iv) in vivo and clinical trial studies were selected on the basis of authenticity. Exclusion criteria: (i) studies not published in English; (ii) in vivo studies not followed ethical guidelines; (iii) studies not available in full text. A literature search is carried out on Scopus, PubMed, Google Scholar, Elsevier, and Springer using the following keywords in combination: oral health, essential oils, medicinal plants, phytochemicals, periodontitis, dental caries, dental plaque, gingivitis, in vitro, in vivo studies, clinical trials, microbial infections. The last search was performed on 10 May 2021. A total of 417 records were found during database searches. In the first filter, a total of 164 duplicate records were removed. Then, articles that follow eligibility criteria were selected. The following data were collected from studies:

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Eucalyptus globulus extract (tooth and gums tonic), Dose: twice/day (90 days), Application: gel directly applied on tooth surface MIC value of methanol and acetone extract is 0.16 and 0.63 mg/mL, respectively, while MBC value for methanol and acetone extract is 0.31–1.25 mg/mL and 0.31–2.50 mg/mL, respectively [ 62] Last (2013) Brushing teeth with baking soda. Available at: http://www.newhealthguide.org/Brushing-Teeth-With-Baking-Soda.html (Accessed: 1 March 2017). MIC value of bark extract of Lactobacillus acidophilus, Streptococcus sanguinis, S. salivarius, Aggregatibacteractinomycetemcomitans is 40,35,35, and 45, respectively [ 59] Oral diseases are the main worldwide health complications that affect approximately 3.5 billion people worldwide due to their chronic and progressive nature. Most oral diseases can be treated in their early stages and are largely preventable. With the increasing urbanization and changes in lifestyle, mostly in developing countries prevalence of oral diseases continues to increase. The poor access to oral health care facilities in the community, having food and beverages high in sugar, and insufficient exposure to fluoride in toothpaste or water supply will be the reasons behind the increase in oral disease. The most common oral diseases that include clinical conditions affecting mouth and teeth are periodontal (gum) diseases, dental caries (tooth decay), oral cancers, oro-dental trauma, oral manifestations of HIV, cleft lip and palate, and Noma. It was reported in earlier studies that approximately 2.3 billion people suffer from dental caries of permanent teeth [ 1]. In earlier studies, it was reported that approximately 20% of people suffer from oral diseases [ 2]. The cure is lengthy and costly, which consequently results in complications for psychological and facial growth.Salvadora persica oral rinse 50% conc., Dose: 15 mL twice/day (6 months), Application: gargle, mouthwash

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Natural toothpastes are made from natural ingredients, the most common being sodium bicarbonate and clay, but anything that has a scrubbing or plaque removing effect on the teeth could be used," he begins. "In modern toothpastes, people want something with a better taste and something that appeals from a marketing point of view, not just from a functional point of view." Estragol (methyl chavicol), (E)- anethole, capillene, methyl eugenol, (E)-β-ocimene, (E)-α-ocimene, (Z)-β-ocimene limonene, α-pinene, α-terpinolene, isoelemicin, elemicin 5-phenyl-1,3- pentadiyne, α-phellandrene, β-phelland-rene, pulegone, (Z)-artemidin, hinokitiol, and acenaphthene [ 63]A substance that could be found in nature is strawberries. Acids from the white heart of the strawberry could be used as a whitening agent but making it at home is very difficult and not advised. However, the consumption of strawberries will help." The more you know, eh? and β-bisabolenes, α-caryophyllene, β-caryophyllene, cadinene, N-(isobutyl)-2E,6Z,8E-decatrienamide, N-(isobutyl)-6Z,8E-decadienamide, N-(2-methylbutyl)-2E,6Z,8E-decatrienamide, decatrienamide, N-(2-phenylethyl)-2E,6Z,8E-decatrienamide [ 86] Over time, Dr Sioutis adds, people have taken clays and sodium bicarbonate and started adding things like glycerin to make it into a paste, and added other elements to change the colour and the taste. "That said, natural toothpastes don’t have some ingredients that can be very helpful to teeth, like fluoride or enamel repairing ingredients." Will natural toothpaste really clean my teeth? To assess and compare the antigingivitis and antiplaque effect of fluoridated, placebo dentifrice (PD) and 4% tulsi leaf extract dentifrice among 14–15-year-old school children. International Journal of Microbiology: “Antifungal Activity of Essential Oil of Eucalyptus camaldulensis Dehnh. against Selected Fusarium spp.”

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Aerial bark: n-Triacontane, β-sitosterol, Stigmasterol, tetraiacontan-3-one, oleanolic acid and botulin [ 65] In vivo (clinical trial) on humans for efficiency of miswak toothpaste against cariogenic bacteria, Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled TrialIn vivo (clinical trial) on humans for efficiency of mouth wash containing tulsi, VAS score for burning sensation—Pre-treatment (5.33 ± 1.80), Post-treatment (2.44 ± 2.10) Toothache, throat complaints [ 88, 89], Tooth decay [ 90], Sore throat, gum infection [ 91], Gingivitis [ 92] Clinical trial on the action of toothpaste made from the extract of Rosmarinus officinalis on humans divided into two groups (experimental and controlled), assessed at baseline and 30 days after the study using the gingival bleeding index (GBI) and the plaque index (PI).