BMP/Smad; Shh/Gli; TGF-β; WNT/β-catenin; ginseng; human-hair-follicle dermal papilla cells; mouse-hair growth. KRG is a popular herbal medicine used worldwide for a broad range of indications, including diabetes, cardiovascular disease, chronic liver disease, and atopic dermatitis [17- 20]. Many researchers believe that KRG has potential as a therapeutic modality for treatment of many dermatologic diseases. Our previous study showed that KRG may be helpful in treatment of androgenic alopecia [21]. However, there are no studies about the correlation between AA and KRG. Kim et al. [22] reported a potent effect on the recovery of hair follicles by KRG through its combined effects on proliferation and apoptosis of cells in the hair follicle in mouse animal models. These hair growth-promoting effects are associated with components of KRG such as ginsenoside-Rb1 and 20(S)-ginsenoside-Rg3 [23]. Ginsenosides are the major components of KRG, and its anti-allergic and anti-inflammatory effects have already been identified [24]. We think that these anti-inflammatory effects might be linked to the ability to promote hair regrowth. Also, this endorses the above-mentioned autoimmune hypothesis. However, as this is a clinical study, we suppose that further basic studies of the mechanism of KRG in AA may be required. Richard Patterson who age of 45 submitted this photo on his journey with HyunGang Korea Ginseng Hair Regrowth Serum Spray after using for 2 months. Congrats on the success!

Hair-Growth Potential of Ginseng and Its Major Metabolites: A Hair-Growth Potential of Ginseng and Its Major Metabolites: A

The functional aspect of scalp hair is not only to protect from solar radiation and heat/cold exposure but also to contribute to one's appearance and personality. Progressive hair loss has a cosmetic and social impact. Hair undergoes three stages of hair cycle: the anagen, catagen, and telogen phases. Through cyclical loss and new-hair growth, the number of hairs remains relatively constant. A variety of factors, such as hormones, nutritional status, and exposure to radiations, environmental toxicants, and medications, may affect hair growth. Androgens are the most important of these factors that cause androgenic alopecia. Other forms of hair loss include immunogenic hair loss, that is, alopecia areata. Although a number of therapies, such as finasteride and minoxidil, are approved medications, and a few others (e.g., tofacitinib) are in progress, a wide variety of structurally diverse classes of phytochemicals, including those present in ginseng, have demonstrated hair growth-promoting effects in a large number of preclinical studies. The purpose of this review is to focus on the potential of ginseng and its metabolites on the prevention of hair loss and its underlying mechanisms. Oh S.J., Lee S., Kho Y.E., Kim K., Jin C.D., Lim C.J. Stereoselective suppressive effects of protopanaxadiol epimers on uv-b-induced reactive oxygen species and matrix metalloproteinase-2 in human dermal keratinocytes. Can. J. Physiol. Pharmacol. 2015;93:91–95. doi: 10.1139/cjpp-2014-0273.

At almost 50 yrs old and both my Mom and Grandmother went bald, I was so happy to see fine hairs appear on my bald spot just a few days after my very FIRST application of HyunGang Korea Ginseng Hair Regrowth Serum Spray!I feel thatmy regular hair shedding has decreased noticeably since starting the product." By harnessing the power of nature, aims to provide products that are gentle on the skin and promote overall skin health. Richard Patterson who age of 45 submitted this photo on his journey with HyunGang Korea Ginseng Regrowth Hair Spray after using for 2 months. Congrats on the success!

Ginseng Hair Regeneration Spray, Hyungang Korea KORTIN Red Ginseng Hair Regeneration Spray, Hyungang Korea

Ryu HJ, Yoo MG, Son SW. Ryu HJ, et al. Int J Dermatol. 2014 Jun;53(6):e340-2. doi: 10.1111/ijd.12359. Epub 2014 Jan 22. Int J Dermatol. 2014. PMID: 24451023 No abstract available. Dong Hyun K. Review: Herbal medicines are activated by intestinal microflora. Nat. Prod. Sci. 2002;8:35–43. Kesika P, Sivamaruthi BS, Thangaleela S, Bharathi M, Chaiyasut C. Kesika P, et al. Pharmaceuticals (Basel). 2023 Jan 30;16(2):206. doi: 10.3390/ph16020206. Pharmaceuticals (Basel). 2023. PMID: 37259355 Free PMC article. Review.

Alopecia areata (AA) is a common, non-scarring, autoimmune disease that can affect any hair-bearing area. The disease can present as a single, well-demarcated patch of hair loss, multiple patches, or extensive hair loss. It is known to be caused by association with autoimmunity, but the pathogenesis is still uncertain. The prevalence in the general population is 0.1% to 0.2% [1]. The life-time risk of developing AA is estimated by 1.7% [2]. The disease course of AA is unpredictable. About half of patients will convalesce within 1 year, even without treatment [3]. However, most patients will experience more than one episode of hair loss. As a result, these patients can suffer from depression and anxiety [4]. Various therapeutic modalities, including localized or systemic corticosteroids, minoxidil, topical immunotherapy, phototherapy and systemic therapy have been used to treat AA, with variable efficacy and safety profiles. Unfortunately, none of these agents is definitely curative or preventive alone. The most commonly used modality is intra-lesional injection (ILI) of corticosteroids. However, this method is ac-companied by pain in most patients, and the application of ILI in extensive AA or longstanding AA is limited. Also, there are no reports of definite therapies using oral agents, including food, for patients with AA. Damonisa 48 year old Americanmen who was balding at spots for several years. His wife convinced him to try HyunGang Korea Ginseng Hair Regrowth Serum Spray.H eis happy to say he’s noticed that HyunGangimprove fullness of hair.