Inositol Complex | PCOS Support | 180 Capsules | Myo & D Chiro-Inositol, Folate & Chromium | 6X More D Chiro Inositol for Enhanced Benefits | Quatrefolic® | Vegan | UK Made | Additive Free

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Nordio, M.; Proietti, E. (May 2012). "The combined therapy with myo-inositol and D- chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone". European Review for Medical and Pharmacological Sciences. 16 (5): 575–581. PMID 22774396. Nordio M, Proietti E. The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. Eur Rev Med Pharmacol Sci 2012;16(5):575-81. View abstract. Facchinetti F, Orrù B, Grandi G, Unfer V. Short-term effects of metformin and myo-inositol in women with polycystic ovarian syndrome (PCOS): a meta-analysis of randomized clinical trials. Gynecol Endocrinol 2019;35(3):198-206. View abstract. Phelps DL, Ward RM, Williams RL, et al. Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants. Pediatr Res. 2016;80(2):209-17. View abstract.

Pillai, R.A.; Islam, M.O.; Selvam, P.; Sharma, N.; Chu, A.H.Y.; Watkins, O.C.; Godfrey, K.M.; Lewis, R.M.; Chan, S.Y. Placental Inositol Reduced in Gestational Diabetes as Glucose Alters Inositol Transporters and IMPA1 Enzyme Expression. J. Clin. Endocrinol. Metab. 2021, 106, e875–e890. [ Google Scholar] [ CrossRef] Mejia, R.B.; Summers, K.M.; Kresowik, J.D.; van Voorhis, B.J. A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome. Fertil. Steril. 2019, 111, 571–578. [ Google Scholar] [ CrossRef][ Green Version] Golianopoulos, T. (2012-05-12). "Drug doubles: What actors actually toke, smoke and snort on camera". Wired. Archived from the original on 2012-05-14 . Retrieved 2012-05-14. Caprio, F.; D’Eufemia, M.D.; Trotta, C.; Campitiello, M.R.; Ianniello, R.; Mele, D.; Colacurci, N. Myo-inositol therapy for poor-responders during IVF: A prospective controlled observational trial. J. Ovarian Res. 2015, 8, 37. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] DiSalvo, David. "We Know About Caffeine in Energy Drinks Like Monster, But What About the Other Ingredients?". Forbes . Retrieved 2020-12-22.Gregersen G, Bertelsen B, Harbo H, et al. Oral supplementation of myoinositol: effects on peripheral nerve function in human diabetics and on the concentration in plasma, erythrocytes, urine and muscle tissue in human diabetics and normals. Acta Neurol Scand 1983;67:164-72. View abstract. Inositol used to be thought of as an essential nutrient, which is any nutrient that must be obtained from your diet. However, observations have shown that the liver and kidneys produce inositol from glucose, so it’s not an essential nutrient. Phelps DL, Watterberg KL, Nolen TL, et al. Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants <28 Weeks' Gestational Age: A Randomized Clinical Trial. JAMA. 2018;320(16):1649-1658. View abstract.

Celentano, C.; Matarrelli, B.; Pavone, G.; Vitacolonna, E.; Mattei, P.A.; Berghella, V.; Liberati, M. The influence of different inositol stereoisomers supplementation in pregnancy on maternal gestational diabetes mellitus and fetal outcomes in high-risk patients: A randomized controlled trial. J. Matern. Fetal. Neonatal Med. 2018, 33, 743–751. [ Google Scholar] [ CrossRef] D’Anna, R.; di Benedetto, V.; Rizzo, P.; Raffone, E.; Interdonato, M.L.; Corrado, F.; di Benedetto, A. Myo-inositol may prevent gestational diabetes in PCOS women. Gynecol. Endocrinol. 2012, 28, 440–442. [ Google Scholar] [ CrossRef] [ PubMed]Greff, Dorina; Juhász, Anna E.; Váncsa, Szilárd; Váradi, Alex; Sipos, Zoltán; Szinte, Julia; Park, Sunjune; Hegyi, Péter; Nyirády, Péter; Ács, Nándor; Várbíró, Szabolcs; Horváth, Eszter M. (2023). "Inositol is an effective and safe treatment in polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials". Reproductive Biology and Endocrinology. 21 (1): 10. doi: 10.1186/s12958-023-01055-z. PMC 9878965. PMID 36703143. Myo-inositol was considered a member of the B-vitamin complex and was known as B8 despite not being an essential nutrient, as it can be produced by the body from glucose. As myo-inositol is an FSH second messenger, it is effective in restoring an optimal FSH/LH ratio and regulating the menstrual cycle. This link to FSH can also lead to improved ovarian follicle maturation and higher oocyte quality – potentially increasing reproductive success. women with BMI > 25 and <30 kg/m 2 and fasting plasma glucose ≤126 mg/dL and/or glycemia <200 mg/dL Hallman M, Pohjavuori M, Bry K. Inositol supplementation in respiratory distress syndrome. Lung 1990;168:877-82. View abstract. D- chiro-inositol is an important messenger molecule in insulin signaling. [31] Inositol supplementation has been shown to significantly decrease triglycerides and LDL cholesterol in patients with metabolic diseases. [31]

Costantino, D.; Minozzi, G.; Minozzi, E.; Guaraldi, C. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: A double-blind trial. Eur. Rev. Med. Pharm. Sci. 2009, 13, 105–110. [ Google Scholar] Metabolic syndrome includes several risk factors such as high blood pressure, belly fat, and high blood sugar, which all increase the risk for diabetes and heart disease. In one study, women who were postmenopausal and had metabolic syndrome took inositol supplements for one year. At the end of the year, they all showed improvement in their metabolic syndrome. In fact, 20% of the women no longer met the criteria for having metabolic syndrome. Larner, J. D-chiro-inositol-its functional role in insulin action and its deficit in insulin resistance. Int. J. Exp. Diabetes Res. 2002, 3, 47–60. [ Google Scholar] [ CrossRef] [ PubMed] One six-month study in 80 postmenopausal women with metabolic syndrome found that 4 grams per day of inositol improved insulin sensitivity, blood pressure and cholesterol levels more than a placebo ( 10).Vitagliano, A.; Saccone, G.; Cosmi, E.; Visentin, S.; Dessole, F.; Ambrosini, G.; Berghella, V. Inositol for the prevention of gestational diabetes: A systematic review and meta-analysis of randomized controlled trials. Arch. Gynecol. Obs. 2019, 299, 55–68. [ Google Scholar] [ CrossRef] Arentz S, Smith CA, Abbott J, Bensoussan A. Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis. BMC Complement Altern Med. 2017;17(1):500. View abstract. Celentano C, Matarrelli B, Pavone G, et al. The influence of different inositol stereoisomers supplementation in pregnancy on maternal gestational diabetes mellitus and fetal outcomes in high-risk patients: a randomized controlled trial. J Matern Fetal Neonatal Med. 2020;33(5):743-751. View abstract. Gynecological Endocrinology: “Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS).”

National Institutes of Health. Available online: https://www.nichd.nih.gov/health/topics/spinabifida/conditioninfo/affected-risk (accessed on 22 January 2021). Oleinik, N.V.; Helke, K.L.; Kistner-Griffin, E.; Krupenko, N.I.; Krupenko, S.A. Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation. J. Biol. Chem. 2014, 289, 26383–26394. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] Inositol can be used to produce molecules that are involved in insulin’s action in your cells ( 9). Pundir, J.; Psaroudakis, D.; Savnur, P.; Bhide, P.; Sabatini, L.; Teede, H.; Coomarasamy, A.; Thangaratinam, S. Inositol treatment of anovulation in women with polycystic ovary syndrome: A meta-analysis of randomised trials. BJOG 2018, 125, 299–308. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] Matarrelli, B.; Vitacolonna, E.; D’Angelo, M.; Pavone, G.; Mattei, P.A.; Liberati, M.; Celentano, C. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: A randomized controlled trial. J. Matern. Fetal Neonatal Med. 2013, 26, 967–972. [ Google Scholar] [ CrossRef] [ PubMed]Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I. Role of inositols and inositol phosphates in energy metabolism. Molecules. 2020;25(21):5079. doi:10.3390/molecules25215079 Kamenov, Z.; etal. (2015). "Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance". Gynecological Endocrinology. 31 (2): 131–5. doi: 10.3109/09513590.2014.964640. PMID 25259724. S2CID 24469378. myo-Inositol is the biologically important form of cyclohexane-1,2,3,4,5,6-hexol. It is a meso compound, i.e. optically inactive because it has a plane of symmetry. It was formerly called meso-inositol, but because there are other meso isomers, myo-inositol is now the preferred name. Besides myo-inositol, the other naturally occurring stereoisomers are scyllo-, muco-, D- chiro-, L- chiro-, and neo-inositol, although they occur in minimal quantities in nature. The other possible isomers are allo-, epi-, and cis-inositol. As their names denote, L- and D- chiro inositol are the only pair of enantiomers (mirror-image forms). All the others are meso compounds. [9] Groenen, P.M.; Peer, P.G.; Wevers, R.A.; Swinkels, D.W.; Franke, B.; Mariman, E.C.; Steegers-Theunissen, R.P. Maternal myo-inositol, glucose, and zinc status is associated with the risk of offspring with spina bifida. Am. J. Obs. Gynecol. 2003, 189, 1713–1719. [ Google Scholar] [ CrossRef] Summary of the studies involving myo-inositol as a treatment for ovulation induction, regularization of menstrual cycle or in the pursuit of pregnancy. Study