Impryl - Conception - Fertility Supplement for Men and Women - Maximise Sperm and Egg Quality for Conception - 30 Tablets - Pregnancy Vitamins - Vegan

Product Information

DNA fragmentation is the ‘snipping up’ of DNA in the sperm head, which can contribute towards difficulties in conceiving and/or miscarriage. DNA fragmentation is often treated with strong anti-oxidants such as Vitamin C, Vitamin E, Selenium, CoQ10, Vitamin A and Carotenoids. However, we now know that although they might prevent DNA fragmentation, these strong anti-oxidants can then cause DNA de-condensation, which is the unravelling of the DNA in the sperm head, meaning that conception is not possible at all. Unlike Impryl, many other supplements contain these strong anti-oxidants. Live birth rate (beyond 24 weeks, defined as the birth of a living child) within study period of 15 months.

CoQ10 is found directly in the follicular fluid surrounding an egg and is an anti-oxidant. It works directly inside the mitochondria of cells to energise its internal biological processes. Also known as Ubiquinol it is used in IVF to try and increase egg number and quality. Impryl is a nutritional supplement mainly consisting of vitamin B, which works on the metabolic system by activating the 1-carbon cycle and recycling of homocysteine without the use of any direct strong antioxidant. Therefore, it could be more effective than other nutritional supplements. The cost of Impryl is €30 for each 30 days of use. Funding The study is supported by an unrestricted grant from Goodlife Pharma BV. This company has developed and marketed Impryl. The grant is unrestricted in means that the funder did not have any role in the design of the study, collection, analysis and/or interpretation of data. The investigators have full access to the data and have the right to publish these data separate and apart from any sponsor. We’re surely not out of the woods yet with my wife as we undergo an IVF cycle but the doctors said my semen quality was absolutely top-notch. There must be a certain degree of probability that the event is a harmful and an undesirable reaction to the medicinal product under investigation, regardless of the administered dose.Studies have shown a benefit for women with a diminished ovarian reserve. This evidence comes from a number of small but reasonably powered studies. Think about how the engine of your car produces power but also waste. The car uses a catalytic converter to ensure that toxins are not released into the surrounding environment. This is similar to the mitochondria (the engine) in a cell producing energy and waste. The GSH (the catalytic converter) removes the waste before it can be released into the rest of the cell (the environment) and do damage. What does this have to do with having a baby? Impryl contains activated micronutrients that help your body to produce Glutathione (GSH), the body’s natural antioxidant, and ensures that GSH is produced only when and where it is required, thus delivering balanced support. The micronutrients within Impryl are proven to help prevent both DNA fragmentation and DNA decondensation. 2. Energy Support What is Energy Support? In addition, a per-protocol analysis will be performed for the primary outcome and the secondary outcomes overall pregnancy number, time to pregnancy, number of miscarriages and live birth rate. AEs are defined as any undesirable experience occurring to a subject during the study, whether or not considered related to Impryl. All AEs reported by the subject or observed by the investigator or his staff will be recorded.

Instead of taking a different combination of numerous multivitamins, some of which will be strong antioxidants that may actually damage sperm quality (sperm DNA decondensation), you need to supplement with the right balance of micronutrients for both of you. This will ensure you and your partner’s egg or sperm are of the best quality to conceive.

A recent Cochrane review suggested that antioxidant supplementation in male infertility might improve the outcomes in assisted reproductive technologies. 18 However, the evidence was rated as low, and clinical studies showed contradictory results with sometimes even a negative effect of high doses of antioxidants due to reductive stress as a rebound effect. 19 Alternatives were therefore explored, to support the natural antioxidant defences that are predicted to act within the modulation of the natural cellular homeostasis without generating rebound effects. For example, the use of nutritional supplements supporting DNA methylation and the homocysteine pathway. Homocysteine is the end product of the 1-carbon cycle, feeding DNA methylation,and the starting substrate for the thiol GSH (l-γ-glutamyl-l-cysteinyl-glycine) de novo biosynthesis. GSH is the most important endogenous antioxidant, involved in maintaining the antioxidant balance in human tissues and directly involved in the elimination of ROS. 20 Homocysteine is an inhibitor of the methylation process and a powerful pro-oxidant. It has a negative effect on spermatogenesis, and its concentration in the ejaculate is inversely correlated with fertility outcome. 21 22 Dattilo et al stated that the ideal supplement should work by favouring homocysteine recycling by restoring the efficiency of the 1-carbon cycle, therefore ensuring the availability of activated methyl groups for DNA methylation and feeding the intracellular antioxidant system by supporting GSH synthesis. 23 In non-randomised pilot studies with such a 1-carbon cycle supporting nutritional supplement Condensyl, the precursor of Impryl, there was a significant decline of DNA fragmentation index leading to an improvement of the clinical pregnancy rate. However, the quality of these studies for the impact on pregnancy rate is rather low due to the non-randomised nature and having no control group. 21 24 25 Furthermore, the ideal parameters to measure DNA damage might not be DNA fragmentation but sperm-oxidation level which indirectly affects DNA damages. 26 27 Time to pregnancy defined as (1) the time between randomisation and reaching ongoing pregnancy (confirmed by ultrasound) and (2) the time between start of fertility treatment during the study (EM, IUI and IVF/ICSI) and reaching ongoing pregnancy. We were about to start ivf… our ivf has been delayed a few times due to bad timing of my period which I had to have tablets for to start my period.